To develop a quantitative approach to personalized risk assessment for stroke and dementia based on patent-specific heart anatomy, function and blood flow.
Cardiac Hemodynamics; Medical Imaging Physics; Continuum Mechanics; Computational Fluid Dynamics
Structure and function of the atria (= top chambers) of the heart are significantly more complex than those of the ventricles (= bottm chambers). Echocardiography is limited by the inability to view the whole atria, and MRI is limited by low spatiotemporal resolution. Dr. Ashikaga’s contribution was to develop and validate a noninvasive method to quantify three-dimensional (3-D) regional function of the atria using a 3-D motion-estimation CT (ref 3). Dr. Ashikaga demonstrated that depressed LA (ref 5) and LA appendage function (ref 6) are associated with a history of stroke/transient ischemic attack (TIA) in individuals with a history of atrial fibrillation (Afib). Dr. Ashikaga also developed a CFD-based technology to estimate LA blood flow from the patient-specific cardiac structure and function defined by cardiac CT to investigate a mechanistic link among the LA structure, function, blood flow, and intracardiac thrombosis leading to stroke (ref 7).
Peer-Reviewed Original Research Articles:
Work in progress: